Curcumin and cancer formation

CURCUMIN AND ITS EFFECT ON CANCER FORMATION

The benefits are shown in all stages of cancer formation: initiation, promotion and progression.
-Inhibits the formation of cancer causing nitrosamines
-enhances the body's production of cancer fighting compounds such as glutathione
-promotes the liver's proper detoxification of cancer causing compounds
-prevents over production of cyclooxygenase 2 (cox2) *1-5
Curcumin inhibits cancer growth:
-Inhibiting epidermal growth factor *4
-Inhibiting angiogenesis *5
-Inhibiting nuclear factor kappa beta (NF-kb) *4
-Increasing expression of the nuclear p53 protein *4
-Inhibiting growth promoting enzymes *4
Experimental studies have found curcumin fights tumours arising from prostate, breast, skin, colon, stomach and liver cancers.*6-13

*1 Li, JK, Lin-Shia SY. Mechanisms of cancer chemoprevention by curcumin. Proc Natl Sci Counc Republic of China B 2001; 25:59-66
*2 Chen H, Zhang ZS, Zhang YL, Zhou DY. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing aptosis. Anticancer res 1999; 19:3675-80
*3Menon LG, Kuttan R, Kuttan G. Anti-metaatatic activity of curcumin and catechin. Cancer lett 1999; 141:159-65
*4 Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S. Curcumin causes the growth arrest and aptosis of B cell lymphoma by downregulation of erg-, c-myc, bcl-XL, NF-kappa B, and p53. Clin immunol 1999; 93:152-61
*5 Arbiser JL, Klauber N, Rohan R, et al. Curcumin ia an in vivo inhibitor of angiogenesis. Mol Med 1998; 4:376-83

Other references upon request